Gynecologic Pathology- Pap Smear I

Question No. 9. The Answer is: (D) Herpes simplex.

Discussion: The typical viropathic cytologic features of Herpes simplex virus infection in both Pap smear and histologic sections include multinucleated nuclei, nuclear molding, and margination of nuclear material, the so-called “3-M” of Herpes Simplex infection. Ground glass nuclei is an additional feature.

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