Gestational Trophoblastic Disease

Question No. 15. The Answer is: (C) Ki-67 activity is increased.

Discussion: Exaggerated placental site is considered a physiologic process that usually has a low proliferation index, thus a low Ki-67. EPS associated with complete hydatiform moles(CHD) can have atypical implantation site intermediate trophoblastic cells that may show a higher Ki-67 than those not associated with CHD.

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