Central Nervous System- Basic Neuropathology
Question No. 15. The Answer is: (C)- Medial longitudinal fascicle.
Discussion:
Medial longitudinal fascicle (MLF) forms the ventral border of the occulomotor and tochlear nucleus in the pons. MLF serves an important function in coordinating the movement of the eye in vision by interconnecting the occulomotor nuclei, trochlear nuclei and abducens nuclei. Bilateral (unilateral much less common) internuclear ophthalmoplegia, so called MLF syndrome, is a classic, and often the initial, manifestation of multiple sclerosis. It is caused by demyelination in MLF. Manifestations of MLF syndrome are featured by weakness in adduction of the ipsilateral eye with nystagmus on abduction of the contralateral eye, and incomplete or slow abduction of the ipsilateral eye upon lateral gaze.