Nervous System- Tumor and Tumor-like lesion I

Question No. 25. The Answer is: (E)  Large cell medulloblastoma.

Discussion: What is being illustrated here is a tumor with significant pleomorphism. In particular, there is "nuclear hugging" (illustrated by the arrow) in this field. Among the answers being provided, "nuclear hugging" and significant pleomorphism are most compatible with large cell medulloblastoma which is also known as anaplastic medulloblastoma. This variant carries a worse prognosis then other variants of medulloblastomas.