Molecular Pathology- Miscellaneous I
Question No. 1. The Answer is: (B) Uterus-endometrium.
Discussion: A proportion (2-4%) of individuals with familial colon cancer have the autosomal dominant disorder known as HNPCC. These individuals display microsatellite instability and mutations in the mismatch repair genes. For women with a constitutional mismatch repair gene mutation, the lifetime risk for endometrial cancer is up to 50%.