Molecular Pathology- Miscellaneous I
Question No. 24. The Answer is: (C) Heterozygous deletion of the BRC gene.
Discussion: The result indicates heterozygous deletion. FISH in this setting typically cannot detect a translocation and definitely cannot detect a single point mutation. If there is homozygous deletion, there will be an absence of signals for the BRC gene while two dots for the control probe will be seen.