Department of Pathology, University of Oklahoma Health Sciences Center
A 28 year-old man with a small nodule on his tongue.
Clinical information: The patient was a 28 year-old man with a small 0.5 cm mucosa covered nodule on the side of his tongue. The polyp was excised for pathologic examination. The followings are the representative images:
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Pathology of the case:
Grossly, the specimen, 1.2 cm in greatest dimension, consists of a nodule of fibrous tissue with tan brown muscle attached to one side. It was submitted entirely for microscopic examination after serial sectioning.
On low magnification, the lesion is a mucosa covered polypoid nodule that is free of ulceration, erosion, and inflammation (Panel A). The resection margin contains muscle of the tongue (M in Panel A). There is some flattening of the epithelial ridges overlying the nodule (Panel B). The nodule does not invade into the skeletal muscle of the tongue (Panel C). On medium magnification, the nodule is composed predominantly of fibrous tissue that contains a low density of spinlde shaped, fibroblast like cells (Panel D and E). On high magnification, many of these spindle cells appear triangular in shape and contains two to three nuclei but are not associated with atypia or nuclear pleomorphism (Panel F, G, and H). Mitoses and necrosis are not readily seen. No hypercellular region is present in the entire specimen.
| DIAGNOSIS: Giant cell fibroma. |
Discussion: Under Preparation
Cases of the Month Evaluation Coordinator: KarMing-Fung@ouhsc.edu