Progressive Rubella Panencephalitis

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Background    Neuroimaging    Gross Pathology    Histopathology & Immunohistochemistry

Differential Diagnosis    Reference

BACKGROUND AND CLINICAL INFORMATION: Head

A sequel of congenital and non-congenital rubella infection. 

Anatomic locations: Cerebrum,. cerebellum, and brain stem.

NEUROIMAGING: Head

GROSS PATHOLOGY: Head

HISTOPATHOLOGY AND IMMUNOHISTOCHEMISTRY: Head

Essentially a demyelinating disease of white matter with extensive involvement of the basal ganglion and brain stem. The cortex is relatively intact.

Widespread neuronal destruction with perivascular lymphocytic infiltration and vasculitis.

Multinucleated giant cells may be seen.

DIFFERENTIAL DIAGNOSIS: Head