Geographic distribution: Seen in rural districts. Can be found North, Central, and South America, Java, and India.

Age: May be acute in children (especially under 1 year old), may be chronic in both adult and children.

Pathogen: Trypanosoma cruzi.

Acute form:

Cerebral edema, congestion and petechial hemorrhage.
Multiple foci of microglial and mononuclear cells without small cell reaction. Leishmania forms of parasite are present within glial cells, or in the center of granulomas.
Neurons are relatively well preserved.
This parasite has a strong tendency to involve muscle.