Department of Pathology, University of Oklahoma Health Sciences Center

NeuroTest Sample Question #39 Next question Previous question

Answer:  A (Seen in cerebellum, immunoreactive for synaptophysin, WHO grade I tumor) Level of difficulty: 4 NeuroTest NeuroLearn NeuroHelp

Discussion: 

• This diagnosis in this case is cerebellar liponeurocytoma. They are rare, benign tumors that are most commonly seen in the 5^th and 6^th decade. Historically, it has been reported under different names. The most distinctive feature of cerebellar liponeurocytoma is the presence of lipidized cells that are indistinguishable from mature adipose cells admixed with clear cell component that displays morphologic features and immunohistochemical profile of supratentorial neurocytoma. Given their well differentiated, neurocytic nature, it is not surprising that cerebellar liponeurocytoma is biologically benign and is classified as histologic grade I tumor out of the 4 tier system according to the World Health Organization Classification. Surgical treatment appeared to be a cure in most cases although rare, and late recurrences at 5-10 years after resection have been reported. Immunohistochemically, the clear cell component are reactive for synaptophysin and neu-N. A useful feature to separate them from oligodendrogliomas. [Click here to see a related case]

Comment: KarMing-Fung@ouhsc.edu