OU Neuropathology Lecture Series (NPLS)

Academic Years 2008-2010

   Lecture of this Month 

 NeuroLearn Case of the Month Dept. of Pathology Dept. of Neurology OU Health Sciences Center

The Neuropathology Lecture Series (NPLS) is a monthly didactic lecture that follows a 2-year cycle and is given by the staff of the Neuropathology Service, Department of Pathology. Guest speakers from and outside the University of Oklahoma Health Science Center are also invited to speak. In general, the lectures are given at noon on the second Friday of every month and most of them will be given in the Neurology Library at the 2nd floor of Presbyterial Professional Building.  The date, title and location of guest lectures will be announced later. Sponsor: Department of Pathology and Neurology, OUHSC.

 

Lecture Date and Location Guest Title of the Lecture
1

09/29/2008, Monday

Lecture: Noon, Hensley Library,  BMSB 451,  (Pathology Grand Round)

Unknown Conference: 8:00 a.m., location to be announced

 Roger E. McClendon, M.D. Department of Pathology, Duke University Medical Center, Durham, NC. i Glioma Research, Diagnosis, and Therapy - A Neuropathologist's View
2 02/03/2009, Tuesday

Lecture: 8:00 a.m.,  Neurology Library, PPB 2nd Floor (Neurology Grand Round)

Unknown Conference: Noon, Neurology Library

 Clayton Wiley, M.D., Ph.D. Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA. i Neuroinflammation in Neuro-degeneration
3 06/29/2009, Monday

Lecture: Noon, Hensley Library,  BMSB 451,  (Pathology Grand Round)

Unknown Conference: 8:00 a.m., location to be announced

 Alexander R. Judkins, M.D. Department of Pathology, Children's Hospital of Philadelphia and the University of Pennsylvania, Philadelphia, PA .i Immunohistochemical detection of INI1 expression: a new tool for old challenges in CNS and pediatric pathology.
4 09/29/2009, Tuesday

Lecture: 8:00 a.m.,  Neurology Library, PPB 2nd Floor (Neurology Grand Round)

Unknown Conference: Noon, Neurology Library

 Douglas C. Miller, M.D., Ph.D. Department of Pathology,

University of Missouri School of Medicine, Columbia, MO. i

 Pathologist/Neuropathologist Medical-Legal Expert Vignettes: A 25 Year Perspective From Malpractice to Homicide

 

Lecture Date Core Lecture (OU Neuropathology Staff) Lecturer  Supplementary Material
   

2008-2009

    
1

07/11/2008, Friday

Location: Pathology Library, BMSB 4th floor, Noon

(Pathology residents only)

Introduction to Neuropathology

Learning Objectives:

·          Birds eye view on the type of neuropathologic process.

·          Introduction to histologic techniques in neuropathology.

·          Capsule review on developmental, macroscopic, and microscopic anatomy.

 Fung i i i ¯ ¯ ss
2

07/25/2008, Friday

Location: Pathology Library, BMSB 4th floor, Noon

(Pathology residents only)

 Trauma

Learning Objectives:

·          Pathology of blunt (closed cranial) trauma.

·          Pathology of penetrating (low velocity and high velocity) trauma.

·          Pathology of shaken-impact baby syndrome and child abuse.

 Stolzenberg ¯ ¯ ¯ s
3

08/01/2008, Friday

Location:  Neurology Library, PPB 2nd floor, 7:30 a.m.

(Neurology residents only)

Introduction to Neuropathology I

Learning Objectives:

·          Birds eye view on the type of neuropathologic process.

·          Introduction to histologic techniques in neuropathology anatomy.

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4

08/06/2008, Wednesday

Location:  Neurology Library, PPB 2nd floor, 7:30 a.m.

(Neurology residents only)

Introduction to Neuropathology II

Learning Objectives:

·          Capsule review on developmental, macroscopic, and microscopic anatomy.

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5

08/08/2008, Friday

Location: Neurology Library, PPB 2nd floor, Noon

 Muscle biopsy I - Introduction and inflammatory myopathies

Learning Objectives:

·          Introduction to the types of myopathic processes.

·          Review of histochemical techniques.

·          Review on structure of the peripheral nervous system.

·          Pathology of inflammatory myopathies.

 Fung i i i i ¯ 0 0 0 0 ss
6

09/12/2008, Friday

Location: Neurology Library, PPB 2nd floor, Noon

 Muscle biopsy II -Dystrophic, Metabolic, and Congenital myopathies

Learning Objectives:

·          Understand dystrophinopathies and other dystrophies.

·          Understand x-linked myotubular myopathy, centronuclear myopathy, and central core disease.

·          Understand mitochondrial myopathies (MELAS) and glycogen storage diseases (McArdle disease).

 Fung 0 0 0 0 0 0s
7

10/10/2008, Friday

Location: Neurology Library, PPB 2nd floor, Noon

 Surgical Neuropathology I - Introduction

Learning Objectives:

·          Introduction to the classification of brain tumors.

·          Brief review of specialized techniques including FISH.

·          Brief discussion on the WHO classification.

 Stolzenberg ¯¯¯s
8

11/14/2008, Friday

Location: Neurology Library, PPB 2nd floor, Noon

 

 Surgical Neuropathology II - Embryonal tumors

Learning Objectives:

·          Understand the diagnostic criteria and shared properties of CNS tumors with embryonal features.

·          Understand the different types of rosettes.

·          Understand the molecular pathology techniques that are used in embryonal tumors.

 Fung 0 0 ssss
9

12/12/2008, Friday

Location: Neurology Library, PPB 2nd floor, Noon

 Surgical Neuropathology III - Glial tumors

Learning Objectives:

·          Understand the WHO classifications on glial tumors.

·          Understand the diagnostic criteria on astrocytic, oligodendroglial, ependymal, and mixed tumors.

·          Understand the molecular mechanism of tumor progression and their impact on diagnosis and therapy.

 Fung i ¯¯ 0 0 0 0 0 0 0 0 ssss
10

01/09/2009, Friday

Location: Neurology Library, PPB 2nd floor, Noon

 Perinatal neuropathology

Learning Objectives:

·          Brief review on developmental anatomy.

·          Learn to correlate pathologic changes with developmental milestones.

·          Understand the pathology of periventricular (germinal matrix) hemorrhage and periventricular leukoencephalopathy (PVL).

·          Understand the pathology of perinatal ischemic hypoxic injuries.

 Fung 0 0 s s
11

02/13/2009, Friday

Location: Neurology Library, PPB 2nd floor, Noon

 Demyelinating diseases

Learning Objectives:

·          Understand the pathologic mechanisms and diagnostic of demyelinating diseases and the special features of “variation on the same theme” in different demyelinating diseases.

·          Be familiar on the special staining techniques required for the diagnosis of demyelinating diseases.

·          Learn the pathology of central pontine myelinolysis.

 Fung 0 0 0
12

03/13/2009, Friday

Location: Neurology Library, PPB 2nd floor, Noon

 Surgical Neuropathology IV- Glial-neuronal and neuronal tumors

Learning Objectives:

·          Understand the WHO classification on neuronal and  and glial-neuronal tumor.

·          Understand the spectrum of this family that goes from pure neuronal to glial-neuronal phenotypes.

·          Familiar with the diagnostic criteria of common glial-neuronal tumors.

·          Understand the relationship between these tumors and cortical dysplasia.

 Fung 0 0 0 0 0 0 0 0s
13

04/10/2009, Friday

Location: Neurology Library, PPB 2nd floor, Noon

 Infection I - Bacteria and parasites

Learning Objectives:

·          Learn the pathology of common infections and the morphology of some parasites.

·          Understand the use of special stain and molecular biology techniques in the diagnosis of CNS infections.

·          Understand the limitation in the use of microscope in the diagnosis of infection.

 Fung i i i 0 0 0 0 0 ss
14

05/08/2009, Friday

Location: Neurology Library, PPB 2nd floor, Noon

 Surgical Neuropathology V - Pseudotumors and pseudopseudotumors.

Learning Objectives:

·          Review on several common non-neoplastic pathologic entities that mimic genuine neoplasms.

·          Review on several tumors that histologically mimic a non-neoplastic process.

 Fung 0 0 0
15

06/12/2009, Friday

Location: Neurology Library, PPB 2nd floor, Noon

 Infection II- Virus and fungus

Learning Objectives:

·          Understand the variety of diseases that are caused by viruses and their relation to the immune status of the host.

·          Be familiar with the molecular biology technique and special stain for the diagnosis of viral and fungal infections.

·          Learn the pathology of Rasmussen’s encephalitis.

 Fung 0 0 0 0 0 0 sss
   

2009-2010

    
16

07/10/2009, Friday

Location: Neurology Library, PPB 2nd floor, Noon

 Introduction to Neuropathology

Learning Objectives:

·          Birds eye view on the type of neuropathologic process.

·          Introduction to histologic techniques in neuropathology.

·          Capsule review on developmental, macroscopic, and microscopic anatomy.

 Fung i i i ¯ ¯ ss
17

08/14/2009, Friday

Location: Neurology Library, PPB 2nd floor, Noon

 Application of Neuropathology in Solving Clinical Cases

Learning Objectives:

·          Understand how to use neuropathology in solving clinical cases. Illustrative cases will be discussed.

 Fung  
18

09/11/2009, Friday

Location: Neurology Library, PPB 2nd floor, Noon

 Malformation I - Neural tube defects and related midline defects

Learning Objectives:

·          Review on embryonal development of the CNS.

·          Understand the pathology of neurotube defects.

·          Understand the pathology of midline defects around the central nervous system and also their relationship with the developing CNS and its surrounding organs.

 Fung i i i i 0 0 sss
19

10/09/2009, Friday

Location: Neurology Library, PPB 2nd floor, Noon

 Malformation II - Malformations of the cerebral hemispheres and hydrocephalus

Learning Objectives:

·          Understand the basic pattern of macroscopic pattern formation of the brain.

·          Learn the concept of migration disorder.

·          Review on the common malformations of the cerebral hemispheres.

 Fung i ss
20

11/13/2009, Friday

Location: Neurology Library, PPB 2nd floor, Noon

 Surgical Neuropathology VII - Miscellaneous primary tumors and metastases

Learning Objectives:

·          Learn the pathology of choroid plexus tumors, germ cell tumors, lymphoma, and craniopharyngioma.

·          Understand the pathologic mechanisms of metastases to the CNS and the guideline in differentiating the source of origin.

 Fung 0 0 0 0 0 ss
21

12/11/2009, Friday

Location: Neurology Library, PPB 2nd floor, Noon

 Neurodegenerative disease I - Alzheimer's disease and dementia

Learning Objectives:

·          Review on the architecture of the limbic system.

·          Review in the overall concept of neurodegenerative diseases.

·          Understand the pathologic features of common dementia including Alzheimer’s disease, dementia with Lewy bodies, and Pick’s disease.

 

 Fung  
22

01/08/2010, Friday

Location: Neurology Library, PPB 2nd floor, Noon

 Pituitary and sellar region

Learning Objectives:

·          Learn the pathology of pituitary adenomas and other primary tumors, cysts, and inflammatory lesions of the pituitary glands and sellar region.

 Fung 0 0 0 0
23

02/12/2010, Friday

Location: Neurology Library, PPB 2nd floor, Noon

 Vascular pathology I - Introduction, ischemia and stroke

Learning Objectives:

·          Review on pathology of ischemic/hypoxic injuries in infants and adults.

·          Understand the differences between infants and adults on hypoxic/ischemic injury.

·          Learn the pathologic features of infantile and perinatal hypoxic/ischemic injury and atherosclerosis.

·          Learn the pathologic features of stroke, carbon monoxide poisoning, MELAS, stroke and infarction, hypotension and circulatory arrest.

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24

03/12/2010, Friday

Location: Neurology Library, PPB 2nd floor, Noon

 Neurodegenerative disease II - Parkinson's disease and movement disorders

Learning Objectives:

·          Learn the shared pathology and mechanism of movement disorder.

·          Learn the pathology and diagnostic criteria of Parkinson’s disease, progressive pseudonuclear palsy, cortical basal degeneration and others.

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25

04/09/2010, Friday

Location: Neurology Library, PPB 2nd floor, Noon

 Vascular pathology II - Vasculitis and vasculopathies

Learning Objectives:

·          Compare and contrast the pathology of vasculitis and vasculopathy.

·          Learn the pathologic features of common vasculitis and vasculopathies including primary angiitis of the CNS, CADASIL, and cerebral amyloid angiopathy.

 Fung 0 0 0
26

05/14/2010, Friday

Location: Neurology Library, PPB 2nd floor, Noon

 Vascular pathology III - Vascular malformations and related lesions

Learning Objectives:

·          Learn the pathology of aneurysm, vascular malformation of the brain and spinal cord, and ectomesodermal syndrome associated with vascular malformation.

 Fung i
27

06/11//2010, Friday

Location: Neurology Library, PPB 2nd floor, Noon

 Neurodegenerative disease III - Prion and miscellaneous disorders

Learning Objectives:

·          Learn the pathology of Prion diseases.

·          Learn the pathology of selected degenerative diseases including Wilson’s disease, hepatoencephalopathy, and neuroaxonal degeneration.

 Fung 0

 

Lecture Date Neuropathology Board Review For Neurosurgery Residents Lecturer
1 03/05/09

Brain tumor and space occupying lesions.

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