Department of Pathology, University of Oklahoma Health Sciences Center

Anatomic Pathology Teaching Cases- List by Presentation & Diagnosis

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Bone and Joint

Case No. Title Diagnosis
Case 401-1 A 33 year-old man with an epidural mass in thoracic spine Myeloid Sarcoma
Case 402-2 A 13 year-old girl with a mass in temporal bone Langerhans' cell histiocytosis
Case 304-2 A 25 year-old woman with vertebral/paravertebral mass of the thoracic spine.  Blastomycosis involving the spine with compression fracture and compression of the spinal cord.
Case P-02 A 29 year-old woman with a skull mass for two months. Langerhans' cell histiocytosis
Case P-03 A 15 year-old female with progressive myelopathy. Ewing's sarcoma/primitive neuroectodermal tumor (PNET)
Case 603-2 A 11 year-old boy with a left tibial mass. Adamantinoma, classic type, with pathologic fracture

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Breast

Case No. Title Diagnosis
Case 310-2 A A 65 year-old woman with red nodules on her breast. Angiosarcoma of the breast associated with radiatin therapy
Case 406-2 A 50 year-old woman with a breast mass. Inflammatory myofibroblastic tumor (pseudotumor).

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Dermatopathology

Case No. Title Diagnosis
Case 311-2 A 35 year-old Chinese man with multiple nodules in the neck. Kimura's disease.

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Gastrointestinal Tract

Case No. Title

Diagnosis

Case 404-3 A 2 month-old infant with malrotation. Granular degeneration of smooth muscle of vermiform appendix.
Case 505-2 A 44 year-old woman with abdominal pain. Histoplasmosis (in an HIV seropositive patient).
Case 602-1 A premature neonate (30 weeks of gestation) with feeding problem and abdominal distension. Necrotizing enterocolitis.
Case 602-2 A 54 year-old man with a colonic mass and blood in stool. Amyloidoma.
Case 610-1 A 21 year-old woman with a hepatic mass. Focal nodular hyperplasia.
Case 711-1 A 39 year-old HIV positive man with diarrhea. Cryptosporidiosis.
Case 803-1 A 54 year-old woman with cholelithiasis. Papillomatosis of the gallbladder with focal high-grade dysplasia.
Case 804-1 A 59 year-old woman with prolonged diarrhea for a few months. Collagenous colitis.
Case 808-1 A 54 year-old man with a small colonic polyp. Solitary ganglioneuroma of colon.
Case 809-2 A 52 year-old woman with diabetes, renal failure, and abdominal pain. Gastric mucosal calcinosis.

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Urinary System

Case No. Title Diagnosis
Case 305-1 A 42 year old man with microscopic hematuria. Polypoid cystitis cystica et glandularis, intestinal type.  
Case 410-2 A 55 year-old man with hematuria. Adenocarcinoma in situ of the urinary bladder.
Case 603-1 A 63 year-old woman with diffuse abdominal pain, sharp left upper back pain and a solid mass in the kidney. Mucinous tubular and spindle cell carcinoma.
Case 709-1 A 63 year-old man with bilateral renal masses. Papillary (chromophil) renal cell carcinoma

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Male Genital System

Case No. Title Diagnosis
Case 305-3 A 32 year-old man with primary infertility.  Sertoli cell-only syndrome (germinal cell aplasia), mature (adult) variant.
Case 308-2 A 49 year-old man with a scrotal mass. Angiomyofibroblastoma of the scrotum.
Case 601-2 A 22 year-old man with metastatic mature testicular teratoma in lymph node. High-grade prostatic intraepithelial neoplasm (PIN) in metastasizing mature teratoma.

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Female Genital System (Gynecopathology)

Case No. Title Diagnosis
Case 710-1 A 30 year-old woman with bilateral tubal ligation.  Adenomatoid tumor of fallopian tube.

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Head and Neck

Case No. Title Diagnosis
Case 304-1 A 55 year-old man with rapidly enlarging thyroid mass.  Columnar cell variant of papillary carcinoma (columnar cell carcinoma) of thyroid.
Case 304-3 A 45 year-old man with a mass in left submandibular gland. Adenoid cystic carcinoma, low-grade, of the submandibular gland.
Case 309-3 A 50 year old man with a rapidly enlarging parotid mass. Salivary duct carcinoma ex pleomorphic adenoma.
Case 604-2 A 54 year-old man with bilateral enlargement of submandibular glands and proteinuria. Amyloidosis of salivary gland.
Case 701-1 A 45 year-old man with an ulcer in his hard palate. Necrotizing sialometaplasia.
Case 704-1 A 59 year-old man with a maxillary mass. Malignant melanoma of the maxillary sinus.
Case 805-1 A 60 year-old man with nodule at the tip of the nose. Mucoepidermoid carcinoma, intermediate grade.
Case 806-1 A 60 year-old man with a 2.5 cm mass in the parotid area. Merkel cell carcinoma.
Case 807-1 A 75 year-old man with a mass in the parotid gland. Oncocytoma.
Case 809-1 A 54 year-old man with a swelling between his eyes. Solitary fibrous tumor.
Case 810-1 A 41 year-old woman with leukemia and present with chronic sinusitis.

Invasive fungal infection with Invasive mucormycosis, Rhizopus species, and Aspergillus.

Case 810-2 A 36 year-old woman with a swelling in her left neck. Cervical thymic cyst.

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Hematopoietic System

Case No. Title Diagnosis
Case 401-1 A 33 year-old man with an epidural mass in thoracic spine Myeloid sarcoma
Case 402-2 A 13 year-old girl with a mass in temporal bone Langerhans' cell histiocytosis
Case P-02 A 29 year-old woman with a skull mass for two months. Langerhans' cell histiocytosis
Case 604-2 A 54 year-old man with bilateral enlargement of submandibular glands and proteinuria. Amyloidosis of salivary gland
Case 509-1 A 73 year-old man with an itchy skin rash, hepatosplenomegaly, and increased in level of histamine in urine. Aggressive systemic mastocytosis.

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Lung, Pleura and Mediastinum

Case No. Title Diagnosis
Case 309-1 A 55 year-old woman with a mass in the lung.  Sclerosing hemangioma.
Case 310-3 A 18 year-old man with a mediastinal mass. Yolk sac tumor (endodermal sinus tumor) of the mediastinum.
Case 312-2 A 17 year-old boy with history of hemoptysis Carcinoid. (well-differentiated neuroendocrine carcinoma)
Case 702-1

A 60 year-old, asymptomatic man with multiple nodules in the lung and mediastinal lymphadenopathy.

Langerhans histiocytosis of the lung.

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Oral Cavity, Teeth, and Jaws

Case No. Title Diagnosis
Case 306-2 A 21 year-old man with an asymptomatic mandibular mass. Myxoma of the mandible.
Case 402-1 A 9 month-old girl with a mass in the hard palate Melanotic neuroectodermal tumor of infancy (retinal anlage tumor, melanotic progonoma).

Case 408-1

A 23 year-old man with a mandibular mass. Osteosarcoma, chondroblastic type, low-grade.
Case 610-2 An 8 year-old girl with macroglossia. Plexiform neurofibroma of the tongue in a patient with neurofibromatosis 1 (NF1).
Case 712-1 A 6 year-old boy with a mandibular expansion. Ameloblastic fibroma.

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Neuropathology: Non-Space occupying Lesions

Case No. Title Diagnosis
Case P-01 A 70 year-old man with rigidity, decreased ocular movements, and dementia.  Progress suprnuclear palsy (PSP)
Case 308-1 A 54 year-old man with acute onset pain, delusion, and rapid deterioration. Rabies
Case 501-1 A 10 year-old boy with history of asthma and lower extremity weakness. Eosinophilic myelitis
Case 504-1 An unresponsive 55 year-old woman. Acute hemorrhage in basal ganglia following circulatory arrest.
Case 511-1 A 10 year-old boy with headache, rapid neurologic deterioration, leptomeningeal and parenchymal enhancement. Acute primary amebic meningoencephalitis with Naegleria fowleri.
Case 601-1 A 42 year-old woman with difficulties in walking, confusion, multiple white matter lesions and history of substance abuse. Leukoencephalopathy with vacuolar changes, compatible with cocaine induced vacuolar leukoencephalopathy.
Case 802-1 A 41 year-old man with headache, altered mental status, and large intraventricular hemorrhage. Moyamoya disease associated with massive intraventricular hemorrhage.

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Neuropathology: Muscle and Nerve Biopsy

Case No. Title Diagnosis
Sim01 A 60 year-old man with lower limb weakness, pain, and numbness. Amyloid neuropathy.
Sim06 A full term neonate with severe hypotonia. X-linked myotubular myopathy
Case 305-2 A 5 year-old girl with muscle weakness and pain. Central core disease
Case 310-1 A 56 year-old woman with rash and generalized weakness. Dermatomyositis
Case 401-3 A 56 year-old man with muscle pain and progressive muscle weakness Adenylate deaminase deficiency
Case 404-1 A 52 year-old man with muscle weakness Central nuclear myopathy
Case 410-1 A 76 year-old man with weakness in arms and hands. Desmin related myopathy
Case 411-1 A 23 year-old woman with elevated serum creatine kinase level and muscle weakness. Glycogenosis type V (McArdle's disease)
Case 506-1 A 54 year-old man with fatigue, muscle pain, and elevated creatine kinase. Tubular aggregate myopathy.

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Neuropathology: Space occupying Lesions

Case No. Title Diagnosis
Case P-02 A 29 year-old woman with a skull mass for two months. Langerhans' cell histiocytosis
Case P-03 A 15-year-old female with progressive myelopathy. Ewing's sarcoma/primitive neuroectodermal tumor (PNET)
Sim02 A 21 year-old woman who rapidly becomes quadriplegic. Ependymoma
Sim03 A 10 year-old girl with a hemispheric mass and hydrocephalus. Papillary ependymoma.
Case 304-2 A 25 year-old woman with vertebral/paravertebral mass of the thoracic spine.  Blastomycosis involving the spine with compression fracture and compression of the spinal cord.
Case 306-1 A 45 year-old woman with an enhancing brain mass. Chordoid meningioma
Case 307-1 A 32 year-old woman with a ventricular tumor. Central neurocytoma
Case 309-2 A 5 year-old boy with a cystic lesion in the filum terminale.  Enterogeneous cyst of the spinal cord.
Case 311-1 A 55 year-old man with an enhancing parietal mass. Glioblastoma
Case 402-2 A 13 year-old girl with a mass in temporal bone Langerhans' cell histiocytosis
Com 403-2 A large cerebellar mass Atypical teratoid/ rhabdoid tumor (AT/RT)
Case 404-2 A 18 year-old man with headache, ataxia, and cerebellar mass Blastomycosis encephalitis
Case 401-1 A 33 year-old man with an epidural mass in thoracic spine Myeloid sarcoma
Case 401-2 A 5 year-old boy with nausea and vomiting for 3 months Pilocytic astrocytoma
Case 405-1 A 54 year old woman with headache and vomiting Secretory meningioma
Case 406-1 A 5 year-old boy with a superficially located, partially cystic hemispheric mass. Desmoplastic Infantile Ganglioglioma (DIG) with melanocytic colonization
Case 407-1 A 64 year-old man with an intradural extramedullary spinal mass. Hemangioblastoma
Case 407-2 A 27 year-old man with headache, right side visual field loss, and weakness. Inflammatory demyelinating pseudotumor
Case 408-2 A 55 year-old woman with granulomatous dermatitis and cerebral masses. Non-Hodgkin's lymphoma, large B-cell type, with extensive granulomatous inflammation
Case 409-1 A 13 year-old boy with three years history of seizure. Meningioangiomatosis
Case 409-2 A 4 year-old girl with rapidly expanding cervical intradural, extramedullary mass. Undifferentiated sarcoma.
Case 411-4 A 48 year-old man with a midline cerebellar mass. Cerebellar central liponeurocytoma
Case 411-3 A 40 year-old man with back pain and a sacral mass. Myxopapillary ependymoma
Case 412-1 A 12 year-old girl with an enlarged optic nerve. Pilocytic astrocytoma of the optic nerve (Optic nerve glioma)
Case 501-2 A 65 year-old woman with an intraventricular mass. Subependymoma
Case 502-1 A 28 year-old woman with an intraventricular mass. Choroid plexus papilloma with brain invasion.
Case 503-1 An 18 month-old girl with a hypothalamic mass. Pilomyxoid astrocytoma
Case 505-1 A 28 year-old woman with a pineal mass. Pineal germinoma with extensive granulomatous changes.
Case 507-2 An infant born after 30 weeks of gestation and with a rapidly enlarging head. Congenital craniopharyngioma with severe secondary hydrocephalus.
Case 512-1 A 70 year-old man with confusion and neurologic deterioration after a minor fall. Acute hemorrhage secondary to cerebral amyloid angiopathy.
Case 604-1 A 5 year-old boy with headache, vomiting, ataxia and a pineal mass. Primary mature teratoma of the pineal with growing teratoma syndrome and chemotherapy induced atypia

Case 605-1

A 75 year-old man with progressive weakness and multiple lesions in the brain. Primary T-cell lymphoma of the brain
Case 606-1 A 10 year-old girl with a cerebral hemispheric mass and headache. Papillary ependymoma
Case 611-1 An 8 year-old boy with headache and a mass in the posterior fossa. Large cell (anaplastic) medulloblastoma, WHO grade IV.
Case 706-1 A 67 year-old woman with a cerebellar and parietal enhancing lesions. Diffuse large B-cell lymphoma.
Case 708-1 A 30 year-old man with prolonged history of headache and a cerebellar hemispheric mass. Dysplastic gangliocytoma of the cerebellum (Lhermitte-Duclos disease)
Case 705-1 A 45 year-old woman with new onset seizure and an enhancing mass. Sinus histioicytosis with massive lymphadenopathy (Rosai-Dorfman disease).
Case 707-1 A 52 year-old man with history of endocarditis, stroke, and new enhancing lesion in temporal lobe. Glioblastoma with extensive granular cell component (granular cell glioblastoma), WHO grade IV.
Case 801-1 A rapidly expanding mass in the posterior fossa of a 4 year-old girl. Anaplastic/large cell medulloblastoma, WHO grade IV.
Case 809-1 A 54 year-old man with a swelling between his eyes. Solitary fibrous tumor.

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Pituitary, Sellar and Perisellar

Case No. Title Diagnosis
Case 312-1 A 28 year-old woman with headache and visual disturbance Lymphocytic hypophysitis
Case 403-1 A 45 year-old woman with a sellar mass Rathke's cleft cyst
Case 510-1 A 60 year-old man with a pituitary mass. Pituitary oncocytoma (null cell adenoma with extensive oncocytic changes).
Sim04 A 20 year-old man with a sellar-suprasellar mass and sudden loss of vision. Infarcted pituitary adenoma

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Eye

Case No. Title Diagnosis
Case 411-2 A 2 year-old girl with a funny looking eye. Retinoblastoma

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Soft Tissue

Case No. Title Diagnosis
Case 306-3 A 29 year-old woman with a mass in her thigh. Mesenchymal chondrosarcoma
Case 307-2 A 48 year-old woman with a mass in her thigh. Cellular Myxoma (Low-grade myxoid neoplasm with recurrent potential)
Case 308-2 A 49 year-old man with a scrotal mass. Angiomyofibroblastoma of the scrotum
Case 607-1 A 6 month girl with a mass in her right arm. Fibrous hamartoma of infancy