B Virus Encephalitis

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BACKGROUND AND CLINICAL INFORMATION: Head

Pathogen: Herpes simiae virus.

Transmission: After monkey bite, very rare.

Anatomic locations: Spinal cord or brain stem segment related to the site of a monkey bite.

Manifestation: Transverse myelitis, ascending myelitis and/or encephalitis.

Histology: Intense inflammation and parenchymal necrosis with petechial hemorrhages and neuronophagia in neurons and oligodendrocytes showing features of acute multifocal necrotizing encephalitis. Viral antigen can be demonstrated by immunohistochemistry.